The ability of peer review to improve manuscripts, e.g., conduct, reporting, and validity of study findings, as well as deter publication of “bad” studies is increasingly being questioned. In the past, Mario has made a call to showcase changes that occurred to each study due to peer review. In this talk he reflects on the findings of the living review of changes that occur to manuscripts (or preprints) due to peer review, as well as on the implementation of structured peer review. He also shares considerations on future of peer review, use of LLMs and other models in peer review, and how journals and institutions could guarantee the (computational) reproducibility of research.